Computational problems of compartmental models with Michaelis-Menten-type elimination. A semicompartmental modeling approach for pharmacodynamic data assessment. Direct linear plotting method for estimation of pharmacokinetic parameters. Corticosteroid pharmacodynamics: models for a broad array of receptor-mediated pharmacologic effects. Pharmacokinetics: Statistical moment calculations. Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, 5 th ed. Kinetic Data Analysis: Design and Analysis of Enzyme and Pharmacokinetic Experiments. J Pharmacokin Biopharm 21:457.Įndrenyi, ed. Comparison of four basic models of indirect pharmacodynamic responses. Noncompartmental determination of mean residence time and steady-state volume of distribution during multiple dosing, J Pharm Sci 80:202.ĭayneka, Garg and Jusko (1993). Estimation of statistical moments and steady-state volume of distribution for a drug given by intravenous infusion. ESTRIP, A BASIC computer program for obtaining initial polyexponential parameter estimates. Conditional Weighted Residuals (CWRES): A Model Diagnostic for the FOCE Method, Pharmaceutical Research, DOI:10.1007/s1109-x.īrown and Manno (1978). Additional references are provided below. References for the WinNonlin operational objects are provided in their descriptions.
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